Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)- → HCID 70141342, compound

Participants

Reaction Steps

A solution of Example 270A (1.1 g, 2.4 mmol) and dimethyl acetal (350 mL) in DMF (10 mL) was treated with a catalytic amount of camphorsulfonic acid, stirred at rt for 15 h than partitioned between water ant ethyl acetate. The organics were washed with brine, dried (MgSO4), filtered, concentrated and purified via silca gel column chromatography eluting with 25% hexanes-ethyl acetate to give 693 mg of the title compound as a viscous oil.

Provenance & Evidence