HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl morpholine oxide → HCID 15557311, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl morpholine oxide | HCID 82029 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 3-Methylene-3,4-dihydro-2H-1,5-benzodioxepin | HCID 595450 | — |
| Catalyst | Osmium Tetroxide | HCID 30318 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | HCID 15557311 | HCID 15557311 | — |
Reaction Steps
A cloudy solution of Example 280A (0.81 g, 5 mmol), 4-methylmorpholine N-oxide (644 mg, 5.5 mmol) in t-butanol (0.4 mL), water (2.5 mL) and acetone (1.5 mL) was treated with OsO4 (0.1 mL, 4% aq. solution) then stirred overnight. The reaction mixture was treated with 2 g NaHCO3, concentrated and partitioned between water and EtOAc. The organics were dried (MgSO4), filtered and concentrated to a white solid (740 mg, 75%). MS (ESI): 219 (M+Na)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06294573B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-bcd630c2757549babb9dd36a2d2fa377 |
| Source note | uspto-grants-2001_09 |