4-Methoxybenzamide → HCID 10587480, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 725 mg (4.80 mmol) of 4-methoxybenzamide and 1.0 g (4.80 mmol) of methyl 4-bromo-3-oxo-pentanoate was heated neat at 120° C. for 2 h. The resulting dark slurry was cooled to RT, diluted with 2 mL of dichloromethane and purified by silica gel flash column chromatography using hexane/EtOAc 3/1 as eluent to afford 189 mg of the title compound as a yellow solid: low resolution MS (FAB)m/e 285 (MH+), 284 (M+).

Provenance & Evidence