HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiobenzamide → methyl 2-(5-methyl-2-phenyl-1,3-thiazol-4-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiobenzamide | HCID 683563 | — |
| Reactant | Methyl 4-bromo-3-oxopentanoate | HCID 9815681 | — |
| Product | methyl 2-(5-methyl-2-phenyl-1,3-thiazol-4-yl)acetate | HCID 2775646 | 70% |
Reaction Steps
The title compound (827 mg) was prepared from 1.0 g (4.78 mmol) of methyl 4-bromo-3-oxo-pentanoate and 2.6 g (19.14 mmol) of thiobenzamide according to the method of Intermediate 42 followed by purification via silica gel flash column chromatography using hexanes/EtOAc (3:1) as eluent: low resolution MS (ES) m/e 270 (MNa+), 248 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06294580B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-5af55ae040cc422984d1a6005fb07c28 |
| Source note | uspto-grants-2001_09 |