HuagongsheHuagongshe Chemistry Print Report · For research reference only
H-Tyr(Bzl)-OMe → 3-(4-Hydroxyphenyl)-2-(2-(4-biphenylcarbonyl)-phenylamino)-propionic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | H-Tyr(Bzl)-OMe | HCID 6999558 | — |
| Reactant | 2-(4-Phenylbenzoyl)cyclohexanone | HCID 21700417 | — |
| Product | 3-(4-Hydroxyphenyl)-2-(2-(4-biphenylcarbonyl)-phenylamino)-propionic acid methyl ester | HCID 54363523 | 32.3% |
Reaction Steps
The title compound (830 mg) was prepared from 1.83 g (5.7 mmol) O-benzyl-L-tyrosine methyl ester and 1.59 g (5.7 mmol) of 2-(4-phenylbenzoyl)cyclohexanone (Child, R. G. et.al. J. Pharm Sci 1977, 66(4), 466-76) according to the method of Intermediate 23 followed by purification via silica gel chromatography eluting with 1/9 EtOAc/hexanes: Low resolution MS (Cl) m/e 452 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06294580B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-dfb1ea8e85ef42f69229b791421f043a |
| Source note | uspto-grants-2001_09 |