Bromine → 2-Bromo-1-(3-fluoro-4-hydroxyphenyl)ethan-1-one

HRID 1597609Notes

Reaction equation

HRID 1597609 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][C:7]=1[OH:8].[Br:12]Br>O1CCOCC1>[Br:12][CH2:10][C:9]([C:4]1[CH:5]=[CH:6][C:7]([OH:8])=[C:2]([F:1])[CH:3]=1)=[O:11]

Participants

4

Reactant 2

HCID 24408BromineHCID 27373251-(3-Fluoro-4-hydroxyphenyl)ethan-1-one

Product 1

HCID 179235302-Bromo-1-(3-fluoro-4-hydroxyphenyl)ethan-1-oneYield 99.8%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a stirred solution of 1-(3-fluoro-4-hydroxyphenyl)-1-ethanone (2.0 g, 12.98 mmol) in dioxane (3 ml) was added a solution of bromine (2.09 g, 13.1 mmol) in dioxane (12 ml), and the mixture was stirred for 16 hours. The mixture was concentrated in vacuo to give title compound (3.02 g, 99% yield). The compound was used for next reaction without purification.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-1c1f14ced9ac4a34b39d23ba151dea33
Source dataset
uspto-grants-2001_09
Patent number
US06294558B1

Reaction notes

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