HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 131721363, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Benzyloxycarbonylglycine | HCID 14349 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | (S)-3-amino-2-benzenesulfonylamino-propionic acid tert-butyl ester hydrochloride | HCID 22853534 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 131721363 | HCID 131721363 | — |
Reaction Steps
Amine 1-5 (0.42 g, 1.25 mmol), Cbz—Gly—OH (288 mg, 1.38 mmol), NMM (0.55 mL, 5.0 mmol) and BOP (829 mg, 1.88 mmol) were combined in 6 mL DMF. After stirring overnight the solvent was evaporated, the residue was taken up in EtOAc, the organic solution was washed with water (2×), 5% KHSO4, sat. NaHCO3 and brine, dried (MgSO4), filtered and concentrated. Flash chromatography (silica, 60% EtOAc/hexane) provided 5-6 as a white glass.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06294549B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-3bd64fcb8033415ebab97d49706d8bb7 |
| Source note | uspto-grants-2001_09 |