HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(Pyridin-4-yl)butanoyl-sarcosine ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Glycine, N-methyl-, ethyl ester | HCID 95849 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | 4-Pyridinebutanoic acid | HCID 3159625 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-(Pyridin-4-yl)butanoyl-sarcosine ethyl ester | HCID 21699762 | — |
Reaction Steps
4-(4-Pyridyl)butanoic acid 10-5 (100 mg, 1.8 mmol), H—Sar—OEt. HCl (300 mg, 2.0 mmnol), BOP (965 mg, 2.2 mmol) and NMM (700 μL, 6.4 mmol) were combined in 9 mL DMF. After stirring overnight the mixture was diluted with EtOAc, washed with water (4×), sat. NaHCO3, and brine, dried (MgSO4), filtered and concentrated. Flash chromatography (silica, 80% to 100% EtOAc/hexane) provided 6-1 as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06294549B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-0c37e6c06aad4412b870ee073c9c85c8 |
| Source note | uspto-grants-2001_09 |