HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Methyl 4-(Pyridin-4-yl)butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Dimethyl 2-(2-(pyridin-4-yl)ethyl)malonate | HCID 21699793 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Methyl 4-(Pyridin-4-yl)butanoate | HCID 12114953 | — |
Reaction Steps
A solution of diester 10-3 (19.0 g, 80.1 mmol), H2O (1.45 ml, 80.1 mmol), NaCl (10.5 g, 160.2 mmol) and DMF was heated to 170° C. for 18 h. The reaction was diluted with EtOAc and then washed with sat. NaHCO3, brine, dried (MgSO4) and concentrated. Flash chromatography (silica, 60% EtOAc/hexanes) afforded ester 10-4 as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06294549B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-331403b5f3444ccb8b4338826428a26a |
| Source note | uspto-grants-2001_09 |