HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(tert-butoxycarbonyl)glycine → N-t-Butoxycarbonylglycyl-3(R)-methyl-beta-alanine benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(tert-butoxycarbonyl)glycine | HCID 78288 | — |
| Reactant | (R)-Benzyl 3-aminobutyrate | HCID 10867189 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | N-t-Butoxycarbonylglycyl-3(R)-methyl-beta-alanine benzyl ester | HCID 86751222 | — |
Reaction Steps
N-(t-Butoxycarbonyl)glycine 14-3 (Aldrich) was coupled with 3(R)-methyl-β-alanine benzyl ester 0.5 H2SO4. 11-7 (Celgene) according to the procedure described for the preparation of 14-5. The title product 15-1 was then obtained by chromatography (silica, hexane/EtOAc 2:3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06294549B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-dc020b383c894434931be5b7482cf149 |
| Source note | uspto-grants-2001_09 |