Ammonia → HCID 54146754, compound

HRID 1597649Notes

Reaction equation

HRID 1597649 reaction equation
[CH2:1]([O:3][C:4](=[O:37])[CH2:5][C@H:6]([NH:13][C:14](=[O:36])[CH2:15][NH:16][C:17](=[O:35])[CH2:18][CH2:19][CH2:20][CH2:21][NH:22][C:23]([NH:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[N+:32]([O-])=O)=[S:24])[C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)C.N>[Pd].CO>[CH3:1][O:3][C:4](=[O:37])[CH2:5][C@H:6]([NH:13][C:14](=[O:36])[CH2:15][NH:16][C:17](=[O:35])[CH2:18][CH2:19][CH2:20][CH2:21][NH:22][C:23]([NH:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[NH2:32])=[S:24])[C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1

Participants

5

Reactant 2

HCID 222AmmoniaHCID 54364193HCID 54364193, compound

Product 1

HCID 54146754HCID 54146754, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

10% Pd/C (50 mg) and 24-6 (103 mg, 0.194 mmol) were added to methanol saturated with ammonia and the mixture hydrogenated at 1 atm. for 18 hr. The reaction was filtered and concentrated to provide 24-7 as a pale yellow gum which was used in the next step without further purification.

Workup

  1. filtrationThe reaction was filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-cf44beb1abcb46f9abead8af23d71523
Source dataset
uspto-grants-2001_09
Patent number
US06294549B1

Reaction notes

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