Bromotrimethylsilane → HCID 15888008, compound

Participants

Reaction Steps

To a solution of 0.53 g (1.49 mmol) 2-(diethylphosphonomethylaminocarbonyl)-7-nitroindole in 7 mL acetonitrile was added 2 mL of bromotrimethylsilane at 0° C. The reaction mixture was allowed to stir at room temperature overnight. The solvent and excess bromotrimethylsilane were removed under reduced pressure and 10 mL of a 1/1 mixture of acetone/water was added and stirred for 24 hours at room temperature. A precipitate formed and the solid was filtered and dried to give 0.45 g (1.47 mmol, 99%) of 2-(phosphonomethylaminocarbonyl)-7-nitroindole.

Provenance & Evidence