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Acetic Anhydride → (2,4-Dihydroxypyrido[3,2-d]pyrimidin-6-yl)methyl acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 反応物 | 2499-96-9 | HCID 273240 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | (2,4-Dihydroxypyrido[3,2-d]pyrimidin-6-yl)methyl acetate | HCID 22281841 | 66% |
反応手順
1.77 g of 1 (10 mmol) in 50 ml of glacial acetic acid containing 6.5 g of MCPBA (57-85%) was refluxed for 3 hours. Acetic anhydride (40 ml) was added to the hot reaction mixture and the refluxing was continued for another half an hour. The clear brown solution was evaporated to dryness and the solid was stirred with ether (100 ml) and filtered. The solid was crystallized from ethanol to give 1.55 g (66%) of 2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05736547 |
| 出典データセット | uspto-grants-1998_04 |
| ORD ID | ord-409e710302ed4ad9b46bafe5c3a98d3f |
| 出典メモ | uspto-grants-1998_04 |