HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-methoxy-3-(2-morpholin-4-ylethoxy)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Isovanillin | HCID 12127 | — |
| Reactant | Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) | HCID 77210 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-methoxy-3-(2-morpholin-4-ylethoxy)benzaldehyde | HCID 3251033 | — |
Reaction Steps
To a solution of 3-hydroxy-4-methoxybenzaldehyde (8.56 g, 56.26 mmol) in CH3CN (50 ml) was added K2CO3 (17.1 g) with CH3CN (20 ml), followed 20 minutes later by N-(2-chloroethyl)morpholine hydrochloride (11.52 g). The reaction mixture was refluxed overnight, and then was cooled to room temperature, filtered, and the solvent was stripped to give, as an amber oil, 4-methoxy-3-[2-(4-morpholinyl)ethoxy]benzaldehyde.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736548 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-68ab783f058d446082b63850f33d025d |
| Source note | uspto-grants-1998_04 |