HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylindoline → 6,7-Dimethoxy-4-(2-methyl-2,3-dihydro-indol-1-yl)-quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylindoline | HCID 23305 | — |
| Reactant | 4-Chloro-6,7-dimethoxyquinazoline | HCID 2769364 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 6,7-Dimethoxy-4-(2-methyl-2,3-dihydro-indol-1-yl)-quinazoline | HCID 18932745 | 91% |
Reaction Steps
Utilizing a procedure analogous to that described in Example 1, this product was prepared in 91% yield from 2-methyl-indoline (1.1 eq.) and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 154°-156.5° C.; GC-MS: 321 (M+); anal. RP18-HPLC RT: 4.93 min.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736534 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-083acebbb5f743dab53868ec88b59971 |
| Source note | uspto-grants-1998_04 |