HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-6,7-dimethoxyquinazoline → 4-(4-Chloro-2,3-dihydro-indol-1-yl)-6,7-dimethoxy-quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-6,7-dimethoxyquinazoline | HCID 2769364 | — |
| Reactant | 4-Chloroindoline | HCID 3016306 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-(4-Chloro-2,3-dihydro-indol-1-yl)-6,7-dimethoxy-quinazoline | HCID 18932747 | 92% |
Reaction Steps
Utilizing a procedure analogous to that described in Example 2, this product was prepared in 92% yield from 4-chloro-indoline (2 eq.) and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 172°-179° C. (dec); LC-MS: 342 (MH+); anal. RP18-HPLC RT: 4.60 min.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736534 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-f10f44894c3f472b96e6e7d799c9f1b3 |
| Source note | uspto-grants-1998_04 |