HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloro-2,3-dihydro-1h-indole → 7-Butoxy-4-(6-chloro-2,3-dihydro-indol-1-yl)-6-methoxy-quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloro-2,3-dihydro-1h-indole | HCID 258567 | — |
| Reactant | 7-Butoxy-4-chloro-6-methoxy-quinazoline | HCID 11780479 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 7-Butoxy-4-(6-chloro-2,3-dihydro-indol-1-yl)-6-methoxy-quinazoline | HCID 18932864 | 43% |
Reaction Steps
Utilizing a procedure analogous to that described in Example 1, this product was prepared in 43% yield from 6-chloro-indoline (1.1 eq.) and 7-butoxy-4-chloro-6-methoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 126°-132° C.; GC-MS: 383 (M+); anal. RP18-HPLC RT: 6.22 min.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736534 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-be56666b88724c5d83bd22c678f19221 |
| Source note | uspto-grants-1998_04 |