HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-6,7,8-trimethoxyquinazoline → 4-(6-Chloro-2,3-dihydro-indol-1-yl)-6,7,8-trimethoxy-quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-6,7,8-trimethoxyquinazoline | HCID 100686 | — |
| Reactant | 6-Chloro-2,3-dihydro-1h-indole | HCID 258567 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-(6-Chloro-2,3-dihydro-indol-1-yl)-6,7,8-trimethoxy-quinazoline | HCID 18932909 | 20% |
Reaction Steps
Utilizing a procedure analogous to that described in Example 1, this product was prepared in 20% yield from 6-chloro-indoline (1.1 eq.) and 4-chloro-6,7,8-trimethoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 139°-143° C.; GC/MS: 371 (M+); anal. RP18-HPLC RT: 4.70 min.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736534 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-c66a990478814585a3ac201247fd0751 |
| Source note | uspto-grants-1998_04 |