HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 18932808, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Chloro-6,7-dimethoxyquinazoline | HCID 2769364 | — |
| Reactant | 6-methoxy-2,3-dihydro-1H-indole | HCID 6427549 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 18932808 | HCID 18932808 | 91% |
Reaction Steps
Utilizing a procedure analogous to that described in Example 1, this product was prepared in 91% yield from 6-methoxy-indoline (1.1 eq.) and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. The HCl salt was generated from the purified free base according to a procedure analogous to that given in Example 2. (M.P. 246°-247° C.(dec); LC-MS: 338 (MH+); anal. RP18-HPLC RT: 4.27 min.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736534 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-5ad33702340c440982775d51416b5dc6 |
| Source note | uspto-grants-1998_04 |