HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 18932763, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Chloro-6,7-dimethoxyquinazoline | HCID 2769364 | — |
| Reactant | 6-Bromo-2,3-dihydro-1H-indole | HCID 13098379 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 18932763 | HCID 18932763 | 88% |
Reaction Steps
Utilizing a procedure analogous to that described in Example 1, this product was prepared in 88% yield from 6-bromo-indoline (1.1 eq.) and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. The HCl salt was generated from the purified free base according to a procedure analogous to that given in Example 2. (M.P. 245°-248° C.(dec); LC-MS: 386, 388 (MH+); anal. RP18-HPLC RT: 4.95 min.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736534 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-1d276c83612348b2868215af0df50934 |
| Source note | uspto-grants-1998_04 |