HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-6,7-dimethoxyquinazoline → 4-(6-Bromo-5-fluoro-2,3-dihydro-indol-1-yl)-6,7-dimethoxy-quinazoline hydrochloride salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-6,7-dimethoxyquinazoline | HCID 2769364 | — |
| Reactant | 6-Bromo-5-fluoroindoline | HCID 21948368 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-(6-Bromo-5-fluoro-2,3-dihydro-indol-1-yl)-6,7-dimethoxy-quinazoline hydrochloride salt | HCID 18932721 | 68% |
Reaction Steps
Utilizing a procedure analogous to that described in Example 1, this product was prepared in 68% yield from 5-fluoro-6-bromo-indoline (1.1 eq.) and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 258° C. (dec); LC-MS: 404, 406 (MH+); anal. RP18-HPLC RT: 5.06 min.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736534 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-77c7e797a61741cebd7edb8bb7bc7e46 |
| Source note | uspto-grants-1998_04 |