Hydrochloric Acid → HCID 54313644, compound

Participants

Reaction Steps

6,7-Dimethoxy-4-(6-nitro-2,3-dihydro-indol-1-yl)-quinazoline (0.50 g, 1.42 mmol; from Example 26) in MeOH (10 mL) with conc. HCl (1 mL) was hydrogenated for 18 hours under 45 psi of H2(g) in the presence of 10% Pd-C (105 mg). Following filtration through a pad of Celite and concentration of the filtrate in vacuo, the residue was taken up in 10% i-PrOH/CHCl3 and the organic phase washed successively with saturated NaHCO3, 0.1M disodium EDTA, and brine. The organic solution was added over Na2SO4(s), filtered and concentrated in vacuo to afford the product as a yellow solid (423 mg; M.P. 215°-217.5° C.; LC-MS: 323 (MH+); anal. RP-HPLC RT: 3.10 min).

Provenance & Evidence