HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-6,7-dimethoxyquinazoline → 4-(4-Bromo-7-methyl-2,3-dihydro-indol-1-yl)-6,7-dimethoxy-quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-6,7-dimethoxyquinazoline | HCID 2769364 | — |
| Reactant | 4-Bromo-7-methylindoline | HCID 18473264 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(4-Bromo-7-methyl-2,3-dihydro-indol-1-yl)-6,7-dimethoxy-quinazoline | HCID 18932874 | 70% |
Reaction Steps
Utilizing a procedure analogous to that described in Example 24, this product was prepared in 70% yield from 4-bromo-7-methyl-indoline (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in DMF. (M.P. 223°-225° C.; LC-MS: 400, 402 (MH+); anal. RP18-HPLC RT: 5.23 min.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736534 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-ab9733a12b6847c0bbc26ef658499b7e |
| Source note | uspto-grants-1998_04 |