HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → HCID 86752367, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | 4-Chloro-6,7-dimethoxyquinazoline | HCID 2769364 | — |
| Reactant | 5-methoxy-2,3-dihydro-1H-indole | HCID 10701974 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86752367 | HCID 86752367 | 95% |
Reaction Steps
Utilizing a procedure analogous to that described in Example 1, this product was prepared in 95% yield from 5-methoxy-indoline (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. The free-base obtained following column chromatography on silica (45% acetone/hexanes) was dissolved in minimal CH2Cl2 and treated with 1 eq. of methanesulfonic acid in CH2Cl2 followed by dilution with several volumes of ether to precipitate the mesylate salt which was filtered and added in vacuo. (M.P. 285°-292° C. (dec); LC-MS: 338 (MH+); anal. RP18-HPLC RT: 3.82 min.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736534 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-1a0e14bc71f94dad9006bc4b9f293e77 |
| Source note | uspto-grants-1998_04 |