HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-6,7-dimethoxyquinazoline → 4-(5-Benzyloxy-2,3-dihydro-indol-1-yl)-6,7-dimethoxy-quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-6,7-dimethoxyquinazoline | HCID 2769364 | — |
| Reactant | 5-(Benzyloxy)-2,3-dihydro-1H-indole | HCID 16794881 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-(5-Benzyloxy-2,3-dihydro-indol-1-yl)-6,7-dimethoxy-quinazoline | HCID 18932804 | 90% |
Reaction Steps
Utilizing a procedure analogous to that described in Example 1, this product was prepared in 90% yield from 5-benzyloxy-indoline (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 181°-182° C.; LC-MS: 415 (MH+); anal. RP18-HPLC RT: 4.78 min.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736534 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-77f357c54e9f4f5b80e3122c26e25c34 |
| Source note | uspto-grants-1998_04 |