HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-7-methylindoline → 4-(4-Bromo-7-methyl-2,3-dihydro-indol-1-yl)-7-methoxy-quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-7-methylindoline | HCID 18473264 | — |
| Reactant | 4-Chloro-7-methoxy-quinazoline | HCID 18925078 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-(4-Bromo-7-methyl-2,3-dihydro-indol-1-yl)-7-methoxy-quinazoline | HCID 18932736 | 69% |
Reaction Steps
Utilizing a procedure analogous to that described in Example 1, this product was prepared in 69% yield from 4-bromo-7-methyl-indoline (1.1 eq.), and 4-chloro-7-methoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 134°-135° C.; LC-MS: 370, 372 (MH+); anal. RP18-HPLC RT: 5.60 min.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736534 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-d841f6d3bacb43a69b8e2d7f12fb1f00 |
| Source note | uspto-grants-1998_04 |