HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(6-Bromo-5-fluoro-2,3-dihydro-indol-1-yl)-7-methoxy-quinazoline hydrochloride salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Chloro-7-methoxy-quinazoline | HCID 18925078 | — |
| Reactant | 6-Bromo-5-fluoroindoline | HCID 21948368 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-(6-Bromo-5-fluoro-2,3-dihydro-indol-1-yl)-7-methoxy-quinazoline hydrochloride salt | HCID 18932877 | 74% |
Reaction Steps
Utilizing a procedure analogous to that described in Example 1 (with conversion to the HCl salt as outlined for Example 2), this product was prepared in 74% yield from 6-bromo-5-fluoro-indoline (1.1 eq.), and 4-chloro-7-methoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 252°-252° C.; LC-MS: 374, 376 (MH+); anal. RP18-HPLC RT: 5.26 min.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736534 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-166346893af24d88abf5b72435c3f01a |
| Source note | uspto-grants-1998_04 |