Pyridinium chloride → HCID 136119078, compound

Participants

Reaction Steps

4-(6-Chloro-2,3-dihydro-indol-1-yl)-7-methoxy-quinazoline (7.596 g, 24.4 mmol; free-base from Example 64) was added in several portions over 5 minutes to molten pyridine hydrochloride (85 g) at 170° C. The stoppered mixture was heated 75 minutes and then poured into ice/water (~600 mL). The precipitated solid was filtered, dissolved in 10% i-PrOH/CHCl3, and the organic solution was washed with saturated aqueous NaHCO3 and brine, dried over Na2SO4(s), filtered and concentrated in vacuo to afford 3.14 g. of product. (M.P. 270°-280° C. (dec); LC-MS: 298 (MH+); anal. RP18-HPLC RT: 4.00 min.).

Provenance & Evidence