1,2,3,4-Tetrahydroquinoline → HCID 18932848, compound

HRID 1597974Notes

Reaction equation

HRID 1597974 reaction equation
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.Cl[C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:24][CH3:25])=[C:19]([S:22][CH3:23])[CH:20]=2)[N:15]=[CH:14][N:13]=1>>[N:1]1([C:12]2[C:21]3[C:16](=[CH:17][C:18]([O:24][CH3:25])=[C:19]([S:22][CH3:23])[CH:20]=3)[N:15]=[CH:14][N:13]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 694601,2,3,4-TetrahydroquinolineHCID 14668413HCID 14668413, compound

Product 1

HCID 18932848HCID 18932848, compoundYield 35%

Procedure

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 35% yield from 1,2,3,4-tetrahydroquinoline and 4-chloro-7-methoxy-6-methylsulfanyl-quinazoline. (M.P. 193°-196° C.; LC-MS: 338 (MH+)).

Sources & evidence

ORD record
ord-73a5afb59f1d409d85137dc22fae704b
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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