6-Chloro-2,3-dihydro-1h-indole → HCID 18932852, compound

HRID 1597975Notes

Reaction equation

HRID 1597975 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8]2)=[CH:4][CH:3]=1.Cl[C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[C:19]([CH3:22])[CH:20]=2)[N:15]=[CH:14][N:13]=1>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([CH3:22])[CH:20]=3)[N:15]=[CH:14][N:13]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 2585676-Chloro-2,3-dihydro-1h-indoleHCID 9402174-chloro-6-methylquinazoline

Product 1

HCID 18932852HCID 18932852, compoundYield 15%

Procedure

Utilizing a procedure analogous to that described in Example 24, this product was prepared in 15% yield from 6-chloro-indoline and 4-chloro-6-methyl-quinazoline. (M.P. 138°-41° C.; LC-MS: 296 (MH+)).

Sources & evidence

ORD record
ord-3c97d43f3da04f03ab43520ab26b7154
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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