6-Chloro-2,3-dihydro-1h-indole → 4-(6-Chloro-2,3-dihydro-indol-1-yl)-6,7-dimethyl-quinazoline

HRID 1597976Notes

Reaction equation

HRID 1597976 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8]2)=[CH:4][CH:3]=1.Cl[C:12]1[C:21]2[C:16](=[CH:17][C:18]([CH3:23])=[C:19]([CH3:22])[CH:20]=2)[N:15]=[CH:14][N:13]=1>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[C:12]2[C:21]3[C:16](=[CH:17][C:18]([CH3:23])=[C:19]([CH3:22])[CH:20]=3)[N:15]=[CH:14][N:13]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 2585676-Chloro-2,3-dihydro-1h-indoleHCID 189328944-Chloro-6,7-dimethylquinazoline

Product 1

HCID 189328554-(6-Chloro-2,3-dihydro-indol-1-yl)-6,7-dimethyl-quinazolineYield 16%

Procedure

Utilizing a procedure analogous to that described in Example 24, this product was prepared in 16% yield from 6-chloro-indoline and 4-chloro-6,7-dimethyl-quinazoline. (M.P. 199° C.; LC-MS: 310 (MH+)).

Sources & evidence

ORD record
ord-86c2e410d5e24a518ac7bbefc5797d98
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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