4,7-Dichloroquinazoline → HCID 18932715, compound

HRID 1597977Notes

Reaction equation

HRID 1597977 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8]2)=[CH:4][CH:3]=1.Cl[C:12]1[C:21]2[C:16](=[CH:17][C:18]([Cl:22])=[CH:19][CH:20]=2)[N:15]=[CH:14][N:13]=1>>[Cl:22][C:18]1[CH:17]=[C:16]2[C:21]([C:12]([N:8]3[C:9]4[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:10]=4)[CH2:6][CH2:7]3)=[N:13][CH:14]=[N:15]2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 2418814,7-DichloroquinazolineHCID 2585676-Chloro-2,3-dihydro-1h-indole

Product 1

HCID 18932715HCID 18932715, compoundYield 50%

Procedure

Utilizing a procedure analogous to that described in Example 24, this product was prepared in 50% yield from 6-chloro-indoline and 4,7-dichloro-quinazoline. (M.P. 189° C.; LC-MS: 316 (MH+)).

Sources & evidence

ORD record
ord-c88ac050a5d24a3bb8ded410a38db427
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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