4,8-dichloroquinazoline → HCID 18932900, compound

HRID 1597978Notes

Reaction equation

HRID 1597978 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8]2)=[CH:4][CH:3]=1.Cl[C:12]1[C:21]2[C:16](=[C:17]([Cl:22])[CH:18]=[CH:19][CH:20]=2)[N:15]=[CH:14][N:13]=1>>[Cl:22][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:16]=1[N:15]=[CH:14][N:13]=[C:12]2[N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:10]=2)[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 2472674,8-dichloroquinazolineHCID 2585676-Chloro-2,3-dihydro-1h-indole

Product 1

HCID 18932900HCID 18932900, compoundYield 47%

Procedure

Utilizing a procedure analogous to that described in Example 24, this product was prepared in 47% yield from 6-chloro-indoline and 4,8-dichloro-quinazoline. (M.P. 190° C.; LC-MS: 316 (MH+)).

Sources & evidence

ORD record
ord-b90b3863c80d4f1fb36ef5f7d5a6ce15
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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