6-Chloro-2,3-dihydro-1h-indole → HCID 18932854, compound

HRID 1597979Notes

Reaction equation

HRID 1597979 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8]2)=[CH:4][CH:3]=1.Cl[C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:23][CH3:24])=[C:19]([Cl:22])[CH:20]=2)[N:15]=[CH:14][N:13]=1>>[Cl:22][C:19]1[CH:20]=[C:21]2[C:16](=[CH:17][C:18]=1[O:23][CH3:24])[N:15]=[CH:14][N:13]=[C:12]2[N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:10]=2)[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 2585676-Chloro-2,3-dihydro-1h-indoleHCID 189328004,6-Dichloro-7-methoxyquinazoline

Product 1

HCID 18932854HCID 18932854, compoundYield 17%

Procedure

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 17% yield from 6-chloro-indoline and 4,6-dichloro-7-methoxy-quinazoline. (M.P. 226° C.; LC-MS: 346 (MH+)).

Sources & evidence

ORD record
ord-e1cf105f53d146a388c472cbe4d32cf0
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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