6-Chloro-2,3-dihydro-1h-indole → HCID 18932754, compound

HRID 1597980Notes

Reaction equation

HRID 1597980 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8]2)=[CH:4][CH:3]=1.Cl[C:12]1[C:21]2[C:16](=[CH:17][C:18]([Cl:24])=[C:19]([S:22][CH3:23])[CH:20]=2)[N:15]=[CH:14][N:13]=1>>[Cl:24][C:18]1[CH:17]=[C:16]2[C:21]([C:12]([N:8]3[C:9]4[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:10]=4)[CH2:6][CH2:7]3)=[N:13][CH:14]=[N:15]2)=[CH:20][C:19]=1[S:22][CH3:23]

Participants

3

Reactant 2

HCID 2585676-Chloro-2,3-dihydro-1h-indoleHCID 18932879HCID 18932879, compound

Product 1

HCID 18932754HCID 18932754, compoundYield 15%

Procedure

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 15% yield from 6-chloro-indoline and 4,7-dichloro-6-methylsulfanyl-quinazoline. (M.P. 167°-168° C.; LC-MS: 362 (MH+)).

Sources & evidence

ORD record
ord-3dacf75365c64dcbbd8202de7e110b6b
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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