4-Chloro-6,7-dimethoxyquinazoline → HCID 18932845, compound

HRID 1597983Notes

Reaction equation

HRID 1597983 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH2:8][NH:9]2)=[CH:4][CH:3]=1.Cl[C:13]1[C:22]2[C:17](=[CH:18][C:19]([O:25][CH3:26])=[C:20]([O:23][CH3:24])[CH:21]=2)[N:16]=[CH:15][N:14]=1>>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH2:8][N:9]2[C:13]2[C:22]3[C:17](=[CH:18][C:19]([O:25][CH3:26])=[C:20]([O:23][CH3:24])[CH:21]=3)[N:16]=[CH:15][N:14]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 138650477-Bromo-1,2,3,4-tetrahydroquinoline

Product 1

HCID 18932845HCID 18932845, compoundYield 11%

Procedure

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 11% yield from 7-bromo-1,2,3,4-tetrahydroquinoline and 4-chloro-6,7-dimethoxy-quinazoline. (film; LC-MS: 399 (MH+)).

Sources & evidence

ORD record
ord-6394cc4540394ff3a0476767c3c251b4
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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