1,2,3,4-Tetrahydroquinoline → HCID 67651119, compound

HRID 1597984Notes

Reaction equation

HRID 1597984 reaction equation
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[CH2:11]([O:13][C:14](=[O:30])[CH2:15][O:16][C:17]1[CH:26]=[C:25]2[C:20]([C:21](Cl)=[N:22][CH:23]=[N:24]2)=[CH:19][C:18]=1[O:28][CH3:29])[CH3:12]>>[CH2:11]([O:13][C:14](=[O:30])[CH2:15][O:16][C:17]1[CH:26]=[C:25]2[C:20]([C:21]([N:1]3[C:10]4[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=4)[CH2:4][CH2:3][CH2:2]3)=[N:22][CH:23]=[N:24]2)=[CH:19][C:18]=1[O:28][CH3:29])[CH3:12]

Participants

3

Reactant 2

HCID 694601,2,3,4-TetrahydroquinolineHCID 54558926HCID 54558926, compound

Product 1

HCID 67651119HCID 67651119, compoundYield 2%

Procedure

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 2% yield from 1,2,3,4-tetrahydroquinoline and (4-chloro-6-methoxy-quinazolin-7-yloxy)-acetic acid ethyl ester. (film; LC-MS: 393 (MH+)).

Sources & evidence

ORD record
ord-45bf51337c5f4a3f92ddedc083a396cf
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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