1,2,3,4-Tetrahydroquinoline → HCID 67650355, compound

HRID 1597985Notes

Reaction equation

HRID 1597985 reaction equation
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[CH2:11]([O:13][C:14](=[O:35])[CH2:15][O:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][C:26]=1[O:27][CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])[N:23]=[CH:22][N:21]=[C:20]2Cl)[CH3:12]>>[CH2:11]([O:13][C:14](=[O:35])[CH2:15][O:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][C:26]=1[O:27][CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])[N:23]=[CH:22][N:21]=[C:20]2[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1)[CH3:12]

Participants

3

Reactant 2

HCID 694601,2,3,4-TetrahydroquinolineHCID 54473771HCID 54473771, compound

Product 1

HCID 67650355HCID 67650355, compoundYield 19%

Procedure

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 19% yield from 1,2,3,4-tetrahydroquinoline and (4-chloro-7-ethoxycarbonylmethoxy-quinazolin-6-yloxy)-acetic acid ethyl ester. (film; LC-MS: 465 (MH+)).

Sources & evidence

ORD record
ord-34b44ed060414d38b80f4c75dcabe30d
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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