Tetrabutylammonium Fluoride → HCID 18932737, compound

Participants

Reaction Steps

To 6,7-dimethoxy-4-(6-trimethylsilanylethynyl-2,3-dihydro-indol-1-yl)-quinazoline (1 eq.; 50 mg; 0.124 mmol) in MeOH (2 mL)/THF (2 mL) was treated with 1M tetrabutylammonium fluoride (2 eq.; 0.248 mL) in THF at 20° C. for 16 hours. Solvents were removed in vacuo and the residue was dissolved in 1:1 EtOAc/Et2O washed with saturated aqueous NaHCO3, dried over Na2SO4(s), filtered and concentrated in vacuo. The product was converted to the HCl salt using a procedure analogous to that described for Example 2. (M.P. 241°-243° C.; LC-MS: 332 (MH+); RP18-HPLC RT: 4.48 min)

Provenance & Evidence