HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 6-chloro-5-nitro-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Borane;pyridine | HCID 2723995 | — |
| Reactant | 6-Chloro-5-fluoro-1H-indole | HCID 2773648 | — |
| Reactant | 6-chloro-5-nitro-2,3-dihydro-1H-indole | HCID 18932902 | — |
| Product | 6-chloro-5-nitro-1H-indole | HCID 18932857 | — |
Reaction Steps
This material was produced from 6-chloro-5-nitro-oxindole (1 eq) and BH3 /THF (6 mol eq.) utilizing a method analogous to that described for 6-chloro-5-fluoro-indole (Preparation 29) in 99% yield (contaminated with some 6-chloro-5-nitro-indoline) and used directly in the subsequent borane/pyridine reduction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736534 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-b0500a985ce943bc94aa95966f762a00 |
| Source note | uspto-grants-1998_04 |