Sodium Carbonate → HCID 86752369, compound

Participants

Reaction Steps

To a solution of (1R,2R,3S)-2-formyl-3-(3,4-dichlorophenyl)tropane (6.9 g, 23 mmol) in methanol (100 ml), sodium carbonate (4 g) and hydroxylammonium chloride (2.6 g, 37 mmol) were added, and the mixture was stirred at room temperature for 18 hours. The reaction mixture was concentrated in vacuo and the residue was triturated with water. A crude product was isolated by filtration and recrystallization first in a mixture of ethanol and water (1+1) and then in 99% ethanol yielded the title compound (mixture of syn/anti isomers--approximately 1+2) as white crystals, m.p. 230°-235° C.

Provenance & Evidence