Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Acetate → N-[4-(4H-Pyrazolo[5,1-c][1,4]benzodiazepin-5(10H)-ylcarbonyl)-3-chlorophenyl]-2-methylbenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 4-[(2-Methylbenzoyl)amino]2-chlorobenzoyl chloride | HCID 10566710 | — |
| 반응물 | 5,10-dihydro-4H-pyrazolo[5,1-c][1,4]benzodiazepine | HCID 13062825 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-[4-(4H-Pyrazolo[5,1-c][1,4]benzodiazepin-5(10H)-ylcarbonyl)-3-chlorophenyl]-2-methylbenzamide | HCID 21837051 | — |
반응 단계
As described for Example 518, a mixture of 0.185 g of 5,10-dihydro-4H-pyrazolo[5,1-c][1,4]benzodiazepine, 0.369 g of 4-[(2-methylbenzoyl)amino]-2-chlorobenzoyl chloride and 0.158 g of diisopropylethylamine in 10 ml of dichloromethane is stirred at room temperature to give crystals (from ethyl acetate) m.p. 241°-244° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05736540 |
| 출처 데이터셋 | uspto-grants-1998_04 |
| ORD ID | ord-835387091d1e4c7bb2a3f96fe6d3ebdc |
| 출처 메모 | uspto-grants-1998_04 |