2-Amino-1-phenylpropan-1-ol hydrochloride → (1S,2R)-(+)-Norephedrine

Participants

Reaction Steps

Phenylpropanolamine hydrochloride was dissolved in the water and to this solution there was added, rapidly with stirring, 20 gm of sodium hydroxide dissolved in 100 ml of water. The mixture was allowed to stand at 10° C. overnight. Crystals of the free base were filtered, washed with water and dried in vacuum over calcium chloride. This process yielded 59 gm of free base phenylpropanolamine.

Provenance & Evidence