2-(Methylamino)ethanol → 2-[(2-Methoxy-benzyl)-methyl-amino]-ethanol
Reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5]Br.[CH3:11][NH:12][CH2:13][CH2:14][OH:15]>>[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][N:12]([CH3:11])[CH2:13][CH2:14][OH:15]Participants
3
Procedure
2-Methoxybenzyl bromide [J.Med. Chem., 32, 1761 (1989)] was reacted with N-methylethanolamine as described in the three previous examples to give N-(2-methoxybenzyl)-N-methylethanolamine which was reacted with 3-chloro-2-(dimethylaminomethyl)phenol in a similar manner to Example 1 (except that conversion into the dihydrochloride salt was omitted) to give the title compound b.p. 100° C. at 0.01 mbar.
Sources & evidence
- ORD record
- ord-acfde8b93412447589d6bc917f0c8cec
- Source dataset
- uspto-grants-1998_04
- Patent number
- US05736568
Reaction notes
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