4-Cyano-4'-[[(2-methoxycarbonylethyl)thiomethyl]-carbonyl]biphenyl → 4-cyano-4'-[N-[[N-(2-methoxycarbonylethyl)-N-methylamino]carbonyl]-N-methylamino]biphenyl

HRID 1598399Notes

Reaction equation

HRID 1598399 reaction equation
Cl.C(N[C:6]1[CH:7]=[C:8]([C:22]2[CH:27]=[CH:26][C:25]([C:28](=[NH:30])N)=[CH:24][CH:23]=2)[CH:9]=[CH:10][C:11]=1OCCCCCC(OC)=O)(=O)C.Cl.C(C1C=CC(C2C=CC(OCCC[CH2:51][CH2:52][C:53]([O:55][CH3:56])=[O:54])=C(NC(=O)C3C=CC=CC=3)C=2)=CC=1)(=N)N.C(C1C=CC(C2C=CC([N:80]([C:82](=[O:90])CCCC(OC)=O)[CH3:81])=CC=2)=CC=1)#N.[C:91](C1C=CC(C2C=CC(S(N(CCCC(OC)=O)C)(=O)=O)=CC=2)=CC=1)#[N:92].C(C1C=CC(C2C=CC(C(CSCCC(OC)=O)=O)=CC=2)=CC=1)#N.C(C1C=CC(C2C=CC(CCSCC(OC)=O)=CC=2)=CC=1)#N.Cl.C(C1C=CC(C2C=CC(S(CCCCC(OC)=O)(=O)=O)=CC=2)=CC=1)(=N)N>>[C:28]([C:25]1[CH:24]=[CH:23][C:22]([C:8]2[CH:7]=[CH:6][C:11]([N:92]([C:82]([N:80]([CH2:51][CH2:52][C:53]([O:55][CH3:56])=[O:54])[CH3:81])=[O:90])[CH3:91])=[CH:10][CH:9]=2)=[CH:27][CH:26]=1)#[N:30]

Participants

8

Reactant 7

HCID 189335254-Cyano-4'-[[(2-methoxycarbonylethyl)thiomethyl]-carbonyl]biphenylHCID 538385434-cyano-4'-[N-(4-methoxycarbonylbutyryl)-N-methylamino]biphenyl2×HCID 543492704-cyano-4'-[[N-(3-methoxycarbonylpropyl)-N-methylamino]sulphonyl]biphenylHCID 545078254-Cyano-4'-[2-(methoxycarbonylmethylthio)ethyl]-biphenylHCID 675762503-Acetylamino-4'-amidino-4-(5-methoxycarbonyl-pentyloxy)biphenyl hydrochlorideHCID 675763754-Amidino-4'-[(4-methoxycarbonylbutyl)sulphonyl]-biphenyl hydrochlorideHCID 675769504-Amidino-3'-benzoylamino-4'-(5-methoxycarbonyl-pentyloxy)biphenyl hydrochloride

Product 1

HCID 537637274-cyano-4'-[N-[[N-(2-methoxycarbonylethyl)-N-methylamino]carbonyl]-N-methylamino]biphenyl

Procedure

(prepared from 4-cyano-4'-[[(2-methoxycarbonylethyl)-aminocarbonyl]amino]biphenyl by methylation with methyliodide) (16) 4-cyano-4'-[[(4-methoxycarbonylpiperidino)-carbonyl]methyloxy]biphenyl (17) 4-cyano-4'-(5-methoxycarbonylpentyloxy)-3'-methylthio]biphenyl (18) 4-cyano-4'-[N-(3-methoxycarbonylpropionyl)-N-methylamino]biphenyl (prepared from 4-cyano-4'-[(3-methoxycarbonyl-propionyl)amino]biphenyl by methylation with methyliodide) (19) 4-cyano-4'-[N-(4-methoxycarbonylbutyryl)-N-methylamino]biphenyl (prepared from 4-cyano-4'-[(4-methoxycarbonylbutyryl)-amino]biphenyl by methylation with methyliodide) (20) 4-cyano-4'-[[N-(3-methoxycarbonylpropyl)-N-methylamino]sulphonyl]biphenyl (prepared from 4-cyano-4'-[(3-methoxycarbonylpropyl)-aminosulphonyl]biphenyl by methylation with methyliodide) (21) 4-cyano-4'-[N-(4-methoxycarbonylbutyryl)-N-methylamino]biphenyl (prepared from 4-cyano-4'-(4-methoxycarbonyl-butyrylamino)biphenyl by methylation with methyliodide) (22) 4-cyano-4'-[[(2-methoxycarbonylethyl)thiomethyl]-carbonyl]biphenyl (prepared from 4-bromoacetyl-4'-cyano-biphenyl and methyl 3-mercaptopropionate) (23) 4-cyano-4'-[2-(methoxycarbonylmethylthio)ethyl]-biphenyl (prepared analogously to (22))

Sources & evidence

ORD record
ord-3e93567174b54afa8aae1d8618abbd54
Source dataset
uspto-grants-1998_04
Patent number
US05736559

Reaction notes

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