HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 15984Generated: October 26, 2026
Diisopropylethylamine → 6-bromo-N2-(quinolin-6-ylmethyl)pyrazine-2,3-diamine
https://huagongshe.com/reaction/15984
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Amino-3,5-dibromopyrazine | HCID 620004 | — |
| Reactant | 6-(Aminomethyl)quinoline | HCID 1514384 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | 6-bromo-N2-(quinolin-6-ylmethyl)pyrazine-2,3-diamine | HCID 45789418 | 49% |
Reaction Steps
A mixture of quinolin-6-ylmethanamine (13 g, 82 mmol), 3,5-dibromopyrazin-2-amine (21 g, 82 mmol) and di-isopropylethylamine (16 mL, 89 mmol) was heated to 130° C. for five hours. The reaction was diluted with dichloromethane:ethanol (9:1) and the resulting suspension was filtered. The precipitate was washed sequentially with water and ether and air dried to afford 6-bromo-N2-(quinolin-6-ylmethyl)pyrazine-2,3-diamine (13 g, 49%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07732604B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-703ad39523e24c928d2fda038c7b0137 |
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| Source note | uspto-grants-2010_06 |
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