HCID 60009260, compound → tert-Butyl (2S)-2-butylpiperazine-1-carboxylate

HRID 1598443Notes

Reaction equation

HRID 1598443 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[C@@H:10]([CH2:21][CH2:22][CH2:23][CH3:24])[CH2:9]1)C1C=CC=CC=1>[Pd]>[C:17]([O:16][C:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][C@@H:10]1[CH2:21][CH2:22][CH2:23][CH3:24])=[O:15])([CH3:20])([CH3:19])[CH3:18]

Participants

3

Reactant 1

HCID 60009260HCID 60009260, compound

Product 1

HCID 15406930tert-Butyl (2S)-2-butylpiperazine-1-carboxylate

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The title compound was prepared according to the procedure described in Example 2, Step C, except using 4-benzyl-1-tert-butoxycarbonyl-2(S)-n-butylpiperazine (3.75 g, 11.3 mmol) and 10% palladium on carbon (0.80 g). The title compound was obtained as an oil (2.68 g). NMR (300 MHz, CDCl3) δ 4.08 (1H, br s), 3.90 (1H, d, J=12 Hz), 2.5-3.8 (6H, m), 1.80 (1H, m), 1.60 (1H, m), 1.46 (9H, s), 1.30 (4H, m),0.90 (3H, t, J=7 Hz).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-83ae54f91011479aaaa5a69b9fbb01c1
Source dataset
uspto-grants-1998_04
Patent number
US05736539

Reaction notes

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