4-Benzyl-1-tert-butoxycarbonyl-2(S)-(2-methoxyethyl)piperazine → (S)-Tert-butyl 2-(2-methoxyethyl)piperazine-1-carboxylate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 2, Step C, except using 4-benzyl-1-tert-butoxycarbonyl-2(S)-(2-methoxyethyl)piperazine (0.280 g, 0.83 mmol) and 10% palladium on carbon (80 mg). The title compound was obtained as an oil (179 mg). NMR (CD3OD, 300 MHz) δ 4.17 (1H, m), 3.81 (1H, dd, J=3, 13 Hz), 3.38 (2H, t, J=6 Hz), 2.82-3.02 (2H, m), 2.77 (2H, ABq, J=4, 13 Hz), 2.59 (1H, dt, J=4, 7 Hz), 2.04 (1H, m), 1.84 (1H, m), 1.46 (9H, s).

Provenance & Evidence