(S)-4-Benzyl-2-(2-hydroxyethyl)piperazine-1-carboxylic acid tert-butyl ester → (S)-tert-butyl 2-(2-hydroxyethyl)piperazine-1-carboxylate

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Reaction Steps

4-Benzyl-1-tert-butoxycarbonyl-2(S)-(2-hydroxyethyl)piperazine (7.0 g, 21.8 mmol) was hydrogenated at 60 psi in methanol (80 mL) in the presence of 10% Pd/C (1.56 g) according to the procedure described in Example 2, Step C. The title compound was obtained as an oil (4.43 g). NMR (CD3OD, 300 MHz) δ 4.17 (1H, m), 3.80 (1H, d, J=4 Hz), 3.54 (2H, t, J=7Hz), 2.75-3.05 (4H, m), 2.58 (1H, dt, J=4, 13 Hz), 2.0 (1H, m), 1.8 (1H, m), 1.45 (9H, s).

Provenance & Evidence