HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 1-tert-butoxycarbonyl-2(S)-(2-(1-propoxy)ethyl)-4-(1-naphthoyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-Iodopropane | HCID 33643 | — |
| Reactant | 1-tert-Butoxycarbonyl-2(S)-(2-hydroxyethyl)-4-naphthoylpiperazine | HCID 12966832 | — |
| Product | 1-tert-butoxycarbonyl-2(S)-(2-(1-propoxy)ethyl)-4-(1-naphthoyl)piperazine | HCID 22884124 | — |
Reaction Steps
The product from Step B was reacted with sodium hydride (0.220 g, 60% dispersion in oil, 5.4 mmol) and n-propyl iodide (0.375 mL, 3.85 mmol) according to the procedure described in Example 7, Step C. The crude product was chromatographed on silica gel with 30% ethyl acetate in hexane. The title compound was obtained as a foam, (0.400 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736539 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-2d3bcb8457f74da8bc6e70e6e8595b84 |
| Source note | uspto-grants-1998_04 |